Clinical Relevance of High-Resolution Single Nucleotide Polymorphism Array in Patients with Relapsed Acute Lymphoblastic Leukemia with Normal Karyotype: A Report of Three Cases
Annals of Laboratory Medicine
; : 132-136, 2015.
Article
in En
| WPRIM
| ID: wpr-64358
Responsible library:
WPRO
ABSTRACT
We report three patients with normal karyotype (NK) ALL, who showed genetic aberrations as determined by high-resolution single nucleotide polymorphism array (SNP-A) analysis at both diagnosis and relapse. We evaluated the clinical relevance of the SNP-A assay for the detection of subtle changes in the size of affected genetic lesions at relapse as well as the prognostic value of the assay. In our patients, application of the SNP-A assay enabled sensitive detection of cryptic changes affecting clinically important genes in NK ALL. Therefore, this assay seems to be more advantageous compared to other conventional methods such as FISH assay, HemaVision (DNA Technology, Denmark), and conventional karyotyping for the detection of an "unstable genotype" at relapse, which may be associated with microscopic clonal evolution and poor prognosis. Further comprehensive studies are required to confirm the issues presented by our case patients in this report.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Recurrence
/
Retinoblastoma Protein
/
In Situ Hybridization, Fluorescence
/
Cyclin-Dependent Kinase Inhibitor p16
/
Loss of Heterozygosity
/
Oligonucleotide Array Sequence Analysis
/
Polymorphism, Single Nucleotide
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Karyotype
/
Genotype
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Annals of Laboratory Medicine
Year:
2015
Document type:
Article