A Case of Spindle Cell Carcinoma Accompanied by Inverted Papilloma / 대한이비인후과학회지

ABSTRACT

Spindle cell carcinoma (sarcomatoid carcinoma) of the upper aerodigestive tract is a rare malignant neoplasm and can be misdiagnosed as reactive lesion or mesenchymal lesion. Spindle cell carcinoma is found predominantly in the larynx and pharynx, but they also occur in the sinonasal tract, oral cavity, and esophagus. The best diagnostic tool of spindle cell carcinoma is immunohistologic staining. Spindle cell reacts positively with cytokeratin and vimentin, but reacts negatively with desmin, smooth muscle actin, collagenIV and s-100 protein. Squamous cell carcinoma is the major malignancy that is associated with inverted carcinoma. To our knowledge, this is the first case report of spindle cell carcinoma accompanied by inverted papilloma, and we represent the case with a review of the related literatures.