Research advances on IL-33 and bronchial asthma / 国际儿科学杂志
International Journal of Pediatrics
; (6): 765-768, 2017.
Article
in Zh
| WPRIM
| ID: wpr-663875
Responsible library:
WPRO
ABSTRACT
IL-33,a recently discovered member of the IL-1 family,is a multifunctional cytokine.It is a-ble to activate variety of cells,including Th2 cells,eosnophils,basophils and mast cells,and then promoting the inflammatory response.Through its receptor ST2,IL-33 activates NF-κB and MAPK signaling pathway,induces production of Th2 cytokines and plays an important role in the occurrence as well as the development of many diseases such as asthma.As such,it is hoped that IL-33 will be a novel therapeutic target for brochial asthma. However,the role of IL-33 in asthma pathogenesis remains unclear yet.Thus,the present review focuses on the molecular structure,expression,biological activity and contribution of IL-33 to the pathogenesis of asthma.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
International Journal of Pediatrics
Year:
2017
Document type:
Article