The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity
Journal of Veterinary Science
; : 325-331, 2015.
Article
in En
| WPRIM
| ID: wpr-66453
Responsible library:
WPRO
ABSTRACT
The bursa of Fabricius (BF) is the acknowledged central humoral immune organ in birds. Bursal septpeptide II (BSP-II) is an immunomodulatory bioactive peptide isolated from BF. To understand the effects of BSP-II on immune induction, gene expression profiles of hybridoma cells treated with BSP-II were evaluated. Pathway analysis showed that regulated genes were involved in cytokine-cytokine receptor interactions, T cell receptor signaling pathway, and pathway in cancer. It was observed that BSP-II reduced tumor cells proliferation and stimulated p53 expression. These results indicate potential mechanisms underlying the effects of the humoral immune system on immune induction, including antitumor activities. Our study has provided a novel insight into immunotherapeutic strategies for treating human tumors.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Bursa of Fabricius
/
Signal Transduction
/
Chickens
/
Oligonucleotide Array Sequence Analysis
/
Avian Proteins
/
Cell Proliferation
/
Transcriptome
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Hybridomas
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Immunologic Factors
/
Antineoplastic Agents
Limits:
Animals
Language:
En
Journal:
Journal of Veterinary Science
Year:
2015
Document type:
Article