Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice
Asian Pacific Journal of Tropical Biomedicine
; (12): 915-920, 2017.
Article
in Zh
| WPRIM
| ID: wpr-667505
Responsible library:
WPRO
ABSTRACT
Objective:
To evaluate the ameliorating effects of Raphanus sativus leaves (RSL) against sodium arsenite(Sa)-induced adverse effects through mice experiments.Methods:
Swiss albino mice were divided into four equal groups control, Sa, RSL, RSL + Sa. Sa (10 mg/kg body weight/day), and powder form of RSL (50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods.Results:
It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase,and aspartate aminotransferase activities were significantly(P<0.05) higher in Sa-treated mice than those in the control group.RSL significantly reduced Sa-induced elevation of the activities of these enzymes in serum significantly (P < 0.05). Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Sa-treated mice were significantly (P < 0.05) lower than the control group, and the food supplementation of RSL could significantly(P<0.05)prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels.RSL could also reduce the Sa-induced elevation of serum urea level significantly(P<0.05).Conclusions:
Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic,cardiovascular and kidney dysfunction.Therefore,RSL may be useful to reduce arsenic toxicity in human in the future.
Full text:
1
Database:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2017
Document type:
Article