Alterations of respiratory resistance in patients with obstructive sleep apnea hypopnea syndrome / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the association between the components of airway resistance and severity of obstructive sleep apnea hypopnea syndrome (OSAHS).</p><p><b>METHODS</b>A total of 234 patients with snoring during sleep underwent full-night polysomnography in our center between January, 2015 and September, 2017. According to the apnea-hypopnea index (AHI) scores, the patients were divided into non-OSAHS group (AHI scores <5), mild or moderate OSAHS group (5-30) group, and severe OSAHS group (>30). The pulmonary function and respiratory resistance of the patients were assessed using spirometry and impulse oscillometry, respectively, and the correlation between the parameters of respiratory resistance and the severity of AHI were analyzed.</p><p><b>RESULTS</b>The non-OSAHS, mild or moderate OSAHS, and severe OSAHS groups consisted of 31, 90 and 113 patients, respectively. The patients with severe OSAHS had significantly higher levels of respiratory resistance at 5 Hz (R5) and 20 Hz (R20), FEF and MMEF than those in the other two groups (P<0.05). Bivariate correlation analysis identified positive correlations of R5 (r=0.259, P=0.000), R20 (r=0.298, P=0.000) and FEF (r=0.176, P=0.007) with AHI scores of the patients.</p><p><b>CONCLUSION</b>Patients with OSAHS have increased respiratory resistance in the large airways and compensatory reduction in small airway resistance.</p>