Research Progress of the Relationship between Circular RNA and Tumorigenesis / 现代检验医学杂志

ABSTRACT

Circular RNA (circRNA) is a special kind of newly confirmed noncoding RNA.CircRNA is a closed cyclic RNA molecule and lack of the 5'end cap and the 3'end of poly (A) tail structure,showing highly conservative and stability.CircRNA is mainly composed of exons,exists in a variety of eukaryotic cells.CircRNA are showed to be the most predominant transcripts compared with linear mRNAs,acting as regulators in transcription or post transcription in almost all kingdoms of life.CircRNA function as competing endogenous RNA to inhibit miRNA activity,involving the regulation of gene transcrip tion and translation.As a new regulatory molecules,circRNA has a dysregulated expression in different kinds of disease including tumor,and may be a newly marker for diagnosis of tumors and prediction the progress of tumors.