Research progress of sodium alginate hydrogels for treating heart failure after myocardial infarction / 中华胸心血管外科杂志

ABSTRACT

Alginate biomaterial is widely used in tissue engineering and regeneration result of its biocompatibility,nonthrombogenic feature,mild and physical gelation process and similarity of its hydrogel matrix texture and stiffness to that of extracellular matrix.In this view,we mainly depict various biomedical applications of alginate hydrogel,such as a supporting cardiac implant in patient after myocardial infraction(M1) and a vector for the controlled delivery and presentation of bioactive moleculars,regenerative factors and cardiac stem cells into the heart,which will reveal therapeutic potential of injectable acellular alginate implants in inhobiting the damaging process after MI,promoting myocardial repair and tissue remodeling.