Linalool Ameliorates Memory Loss and Behavioral Impairment Induced by REM-Sleep Deprivation through the Serotonergic Pathway
Biomolecules & Therapeutics
; : 368-373, 2018.
Article
in En
| WPRIM
| ID: wpr-715618
Responsible library:
WPRO
ABSTRACT
Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula angustifolia, has antioxidant, anti-inflammatory, and neuroprotective effects, along with other effects. However, the effect of linalool on the cognitive impairment and behavioral alterations that are induced by REM-sleep deprivation has not yet been elucidated. Several studies have reported that REM-sleep deprivation-induced memory deficits provide a well-known model of behavioral alterations. In the present study, we examined whether linalool elicited an anti-stress effect, reversing the behavioral alterations observed following REM-sleep deprivation in mice. Furthermore, we investigated the underlying mechanism of the effect of linalool. Spatial memory and learning memory were assessed through Y maze and passive avoidance tests, respectively, and the forced swimming test was used to evaluate anti-stress activity. The mechanisms through which linalool improves memory loss and behavioral alterations in sleep-deprived mice appeared to be through an increase in the serotonin levels. Linalool significantly ameliorated the spatial and learning memory deficits, and stress activity observed in sleep-deprived animals. Moreover, linalool led to serotonin release, and cortisol level reduction. Our findings suggest that linalool has beneficial effects on the memory loss and behavioral alterations induced by REM-sleep deprivation through the regulation of serotonin levels.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Sleep, REM
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Hydrocortisone
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Serotonin
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Cognition Disorders
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Neuroprotective Agents
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Lavandula
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Physical Exertion
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Spatial Memory
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Hippocampus
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Learning
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Biomolecules & Therapeutics
Year:
2018
Document type:
Article