Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression
Biomolecules & Therapeutics
; : 425-431, 2018.
Article
in En
| WPRIM
| ID: wpr-716600
Responsible library:
WPRO
ABSTRACT
Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. It is confirmed that CART peptide exerted inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, Ca2+/calmodulin-dependent kinase signaling and crucial transcription factors expression. Besides modulation of dopamine receptors-related pathways, CART peptide also exhibited elaborated interactions with other neurotransmitter receptors, such as glutamate receptors and γ-aminobutyric acid receptors, which further account for attribution of CART peptide to inhibition of psychostimulant-potentiated locomotor activity. Recently, CART peptide has been shown to have anxiolytic functions on the aversive mood and uncontrolled drug-seeking behaviors following drug withdrawal. Moreover, microinjection of CART peptide has been shown to have an anti-depressant effect, which suggests its potential utility in the mood regulation and avoidance of depression-like behaviors. In this review, we discuss CART pathways in neural circuits and their interactions with neurotransmitters associated with psychostimulant-induced depression.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Phosphotransferases
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Transcription Factors
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Dopamine
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Central Nervous System
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Receptors, Dopamine
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Receptors, Glutamate
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Receptors, Neurotransmitter
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Neurotransmitter Agents
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Depression
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Drug-Seeking Behavior
Language:
En
Journal:
Biomolecules & Therapeutics
Year:
2018
Document type:
Article