The relationship between epicedial adipose thickness and coronary artery in-stent restenosis / 中国医师杂志

ABSTRACT

Objective To investigate the association between epicedial adipose thickness (EAT)and coronary artery in-stent restenosis (ISR).Methods 617 patients underwent review of coronary angiography in one year of drug-eluting stent implantation in our hospital from October 2013 to October 2015 were enrolled in the study.According to the angiography resluts,patients were divided into ISR group and control group.All cases recieved ultrasonic analysis of epicardial adipose thickness and biochemical test.The correlation of EAT,biochemical concentrations and ISR were determined.Results The EAT in ISR group was significantly higher than that in the control group [(7.78 ± 1.32) mm vs (4.19 ± 0.57) mm,t =22.998,P ＜ 0.001].It was also found that the family history of premature coronary artery disease and the severity of coronary artery lessions based on Syntax scores in the IRS group were higher than those in normal control group.Biochemical tests showed that plasma levels of triglycerides and glycosylated hemoglobin were higher,including plasma homocysteine and hypersensitive C-reactive protein (P ＜ 0.05).Multivariates logistic regression analysis suggested that the EAT was associated with ISR [Exp(B) =0.001,P =0.004].Moreover,one-way linear regression showed that EAT was correlated with the severity of IRS (r =0.891,P ＜0.001).Conclusions Epicardial adipose thickness was correlated with the occurrence and severity of coronary artery in-stent restenosis.