Mechanism of insulin resistance in sepsis / 中国小儿急救医学

ABSTRACT

Sepsis, a systemic inflammatory response syndrome caused by infection, is a common cause of death in ICU patients. Current studies suggest that patients with sepsis have stress-induced hypergly-cemia,of which insulin resistance is a direct cause. During sepsis,many factors such as increased hormone release,excessive release of inflammatory mediators and lipogenic factors,oxidative stress,and endoplasmic reticulum stress,lead to the development of insulin resistance by hindering insulin signaling and reducing insulin sensitivity. This article elaborated the mechanism of insulin resistance in sepsis from the above aspects.