USP33, a new player in lung cancer, mediates Slit-Robo signaling
Protein & Cell
; (12): 704-713, 2014.
Article
in En
| WPRIM
| ID: wpr-757656
Responsible library:
WPRO
ABSTRACT
Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker.
Full text:
1
Database:
WPRIM
Main subject:
Pathology
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Physiology
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Prognosis
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Immunohistochemistry
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Receptors, Immunologic
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Signal Transduction
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Down-Regulation
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Gene Expression Regulation, Neoplastic
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Cell Movement
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Blotting, Western
Type of study:
Etiology_studies
/
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Female
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Humans
/
Male
Language:
En
Journal:
Protein & Cell
Year:
2014
Document type:
Article