Molecular Mechanism of Different Signaling Pathways in Regulating PD-L1 Expression in EGFR Mutated Lung Adenocarcinoma / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 875-879, 2018.
Article
in Zh
| WPRIM
| ID: wpr-772350
Responsible library:
WPRO
ABSTRACT
The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and programmed death receptor 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint inhibitors were landmarks in the treatment of non-small cell lung cancer (NSCLC). However, the regulation mechanisms of PD-L1 expression were not fully clear in NSCLC patients with EGFR mutations. Multiple signaling pathways may be involved in the tumorigenesis regulation. This paper summarized and reviewed the potential EGFR mutations impacting on PD-L1 expression with aims to the development of strategies on immunochemical therapy for NSCLC.
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Key words
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Signal Transduction
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Gene Expression Regulation, Neoplastic
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B7-H1 Antigen
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ErbB Receptors
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Adenocarcinoma of Lung
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Genetics
/
Metabolism
/
Mutation
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Lung Cancer
Year:
2018
Document type:
Article