Advances in research and development of new drugs for antiviral therapy for chronic hepatitis B / 临床肝胆病杂志

ABSTRACT

Chronic hepatitis B virus (HBV) infection is one of the major disease burdens worldwide. At present, the antiviral therapy for hepatitis B includes interferons and nucleos(t)ide analogues. Current therapeutic regimens based on these drugs cannot significantly increase the proportion of patients with functional cure. With a better understanding of HBV replication cycle and specific virus-host cell interactions, this article summarizes and reviews the advances in the research and development of new drugs for HBV with a focus on different action targets during the above processes.