Glycogen synthase kinase3 and prostate cancer: An update / 中华男科学杂志
National Journal of Andrology
; (12): 178-182, 2017.
Article
in Zh
| WPRIM
| ID: wpr-812789
Responsible library:
WPRO
ABSTRACT
Glycogen synthase kinase3 (GSK3α and GSK3β) are serine/threonine protein kinases acting on numerous substrates and involved in the regulation of various cellular functions such as their proliferation, survival, glycogen metabolism, and autophagy. Accumulating evidence indicates that the expression of GSK3α is increased mainly in androgendependent while that of GSK3β in androgenindependent prostate cancer, and that GSK3β is also involved in the regulation of the transactivation of the androgen receptor (AR) and growth of prostate cancer. Animal experiments have proved that some GSK3 inhibitors, such as lithium, can significantly suppress tumor growth in different animal models of prostate cancer. The GSK3 inhibitor is promising to be an important agent for the clinical management of prostate cancer.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Prostatic Neoplasms
/
Receptors, Androgen
/
Glycogen Synthase Kinase 3
/
Cell Line, Tumor
/
Drug Therapy
/
Glycogen Synthase Kinase 3 beta
/
Androgens
/
Metabolism
/
Neoplasm Proteins
Limits:
Animals
/
Humans
/
Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2017
Document type:
Article