Auditory evoked potentials index for monitoring the depth of desflurane anesthesia in the elderly / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To observe the changes of auditory evoked potentials (AEP) index, mean arterial blood pressure (MAP) and heart rate (HR) undergoing desflurane anesthesia in the elderly and to evaluate the use of AEP index for monitoring the depth of desflurane anesthesia in the elderly.@*METHODS@#Forty patients classified as ASA physical status I-III undergoing general anesthesia were divided into 2 groups with 20 patients in each group Group elderly (> or =65 years) and Group youth (18-55 years). Anesthesia was induced with propofol and vecuronium. After the endotracheal intubation, the lungs were ventilated with desflurane in oxygen. End-tidal concentration of desflurane was maintained at 0.6 MAC, 1.0 MAC and 1.3 MAC for 20 min, respectively. The changes of MAP, HR and AEP index were recorded simultaneously.@*RESULTS@#During the anesthesia of desflurane, MAP decreased significantly compared with those at preanesthesia in both groups. And HR decreased significantly compared with those at preanesthesia only in Group elderly (P 0.05). During the anesthesia of desflurane, AEP index decreased significantly compared with those at preanesthesia in both groups (P 0.05). At the same concentration of desflurane, AEP index in the Group elderly were less than those in Group youth (P < 0.05). AEP index correlated with the end-tidal desflurane concentration significantly. The coefficient of product-moment correlation (r) were -0.983 and -0.980, respectively in Group elderly and Group youth (P < 0.05).@*CONCLUSION@#AEP index correlates well with the end-tidal desflurane concentration which is valuable for monitoring the depth of desflurane anesthesia in the elderly. AEP index can show the different depth of anesthesia at the same end-tidal desflurane concentration between the elderly and youth.