Sequence polymorphism of the promoter region of gene STK11 in patients with Peutz-Jeghers syndrome / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 74-77, 2007.
Article
in Zh
| WPRIM
| ID: wpr-813934
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To explore the relationship between the sequence variation of the promoter region (-1543 approximately -1160) of STK11 gene and the risk of developing Peutz-Jeghers syndrome (PJS).@*METHODS@#The sequences of the promoter region of 14 PJS patients (7 patients are inherited and the other 7 patients are sporadic) and 42 normal individuals were PCR amplified and then sequenced.@*RESULTS@#A new single nucleotide polymorphism (SNP) G/T (-1275) in STK11 promoter region was identified. The frequency of genotype GG, GT, and TT was 53.3%, 26.7%, and 20%, respectively among PJS patients and 33.3%, 64.3%, and 2.4%, respectively among the normal individuals. The frequency of genotype GG and TT among patients was significantly higher than that among the normal individuals, and the frequency of genotype GT among patients was significantly lower than that among the normal individuals (chi(2)=8.521, P<0.05).@*CONCLUSION@#G/T(-1275) in STK11 promoter region is a new SNP. The genotype of this new SNP may relate to the risk of developing Peutz-Jeghers syndrome (PJS) deserve further research.
Full text:
1
Database:
WPRIM
Main subject:
Polymorphism, Genetic
/
Peutz-Jeghers Syndrome
/
Molecular Sequence Data
/
Base Sequence
/
Promoter Regions, Genetic
/
Protein Serine-Threonine Kinases
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Humans
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2007
Document type:
Article