Association of TNFRSF1B +676 gene polymorphism with the risk of rheumatoid arthritis in Han Chinese population in Hunan / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 891-897, 2016.
Article
in En
| WPRIM
| ID: wpr-815141
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To study the association of TNFRSF1B +676 gene (rs1061622) polymorphism with the risk of rheumatoid arthritis (RA ) in Han Chinese population of Hunan.@*METHODS@#A total of 112 patients with RA from Han Chinese population in Hunan were recruited, along with 129 healthy controls. TNFRSF1B +676 (rs1061622) gene polymorphisms were examined by PCR-RFLP. Serum levels of soluble TNFR II were analyzed by ELISA.@*RESULTS@#RA patients displayed a similar TNFRSF1B +676 genotype to controls (GG/TG/TT 5/62/45 vs 9/56/64, P=0.167), but signifi cant diff erence was found between female RA patients and female controls (GG/TG/TT 3/49/24 vs 8/28/48, P0.05). RA patients showed a signifi cantly higher level of serum soluble tumor necrosis factor receptor II (sTNFR II) than controls [(7.83±2.61) ng/mL vs (4.32±1.67) ng/mL, P0.05). No association was found between TNFRSF1B+676 gene polymorphism and RA clinical characteristics.@*CONCLUSION@#In Han Chinese population of Hunan province, TNFRSF1B+676 gene polymorphisms are not associated with the genetic risk of RA .
Full text:
1
Database:
WPRIM
Main subject:
Polymorphism, Genetic
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Arthritis, Rheumatoid
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Blood
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Risk Factors
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Genetic Predisposition to Disease
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Polymorphism, Single Nucleotide
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Asian People
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Receptors, Tumor Necrosis Factor, Type II
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Alleles
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Ethnology
Type of study:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Female
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Humans
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Male
Language:
En
Journal:
Journal of Central South University(Medical Sciences)
Year:
2016
Document type:
Article