Efficacy and prognostic factors in children with non-core binding factor acute myeloid leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 466-472, 2020.
Article
in Zh
| WPRIM
| ID: wpr-828721
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To compare the efficacy of the CAMS-2005 and CAMS-2009 regimens in treating children with non-core binding factor acute myeloid leukemia (non-CBF AML) and to study the prognosis factors.@*METHODS@#A total of 161 children who were initially diagnosed with non-CBF AML from April 2005 to December 2015 were enrolled as study subjects, and were divided into a CAMS-2005 regimen group (n=52) and a CAMS-2009 regimen group (n=109) according to the chemotherapy regimen provided. The efficacy was retrospectively compared between the two groups.@*RESULTS@#The complete remission (CR) rate at the first course of treatment was higher in the CAMS-2009 regimen group than that in the CMAS-2005 regimen group (63.3% vs 46.2%; P0.05). Children who achieved CR at the first course of treatment had significantly higher OS and event-free survival rates than those who did not achieved CR (P<0.01).@*CONCLUSIONS@#The CAMS-2009 regimen is superior to the CAMS-2005 regimen in improving the CR rate in children with non-CBF AML after induction treatment. Whether CR is achieved at the first course of treatment can affect the OS rate of children with non-CBF AML.
Full text:
1
Database:
WPRIM
Main subject:
Prognosis
/
Remission Induction
/
Leukemia, Myeloid, Acute
/
Antineoplastic Combined Chemotherapy Protocols
/
Retrospective Studies
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Child
/
Humans
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2020
Document type:
Article