Calcium citrate: An interesting organic calcium biomedical material / 中国组织工程研究

ABSTRACT

BACKGROUND: Calcium citrate has been used as calcium supplement, anticoagulant, anti-inflammatory agent and bone repair material in biomedical fields. OBJECTIVE: To describe the basic properties of calcium citrate, summarize and discuss the preparation process of calcium citrate and its main applications in biomedical field. METHODS: The research literature related to calcium citrate was searched on the Web of science, CNKI, Medline and other databases by computer. The main key words were “calcium citrate, bone repairing material, citrate and calcium phosphate” in English and “calcium citrate, bone repair materials” in Chinese. The searching time was from February 1920 to February 2020. RESULTS AND CONCLUSION: With the development and exploration of medical materials, it is necessary to change the original process to improve the biological activity of medical calcium citrate. It is an inevitable trend to obtain calcium citrate with various micro-morphology and high biological activity by controllable synthesis method. Calcium citrate is widely used as calcium supplement, anti-inflammatory agent, anticoagulant, bone repair material and other non-medical applications. Its advantages are being gradually explored by researchers. The preparation method plays a decisive role in the application field of calcium citrate. Different internal structure and size will bring different application fields, from the smallest chemical bond connection to the macroscopic morphology or mechanical properties. These factors may be the results of the dedicated exploration of researchers.