Complications of chronic obstructive pulmonary disease and their effects on prognosis / 解放军医学杂志

ABSTRACT

Objective To explore the morbidity of chronic obstructive pulmonary disease (COPD) related complications and mortality of the COPD patients, and analyze the risk factors for complications. Methods 1829 COPD patients were collected from Department of Respiratory and Critical Care Medicine Center of the Second Affiliated Hospital of Army Medical University and Department of Respiratory of the People's Hospital of Fengdu County from January 2018 to December 2018. Then, the morbidity and mortality of the complication were observed, meanwhile, the risk factors were analyzed by multifactor logistic regression. Results 89.2%(1631/1829) of COPD patients complicated with other diseases, the mortality rate was 2.5%(46/1829). The complications main included respiratory and cardiovascular system diseases, the mortality rates were 68.8% and 34.4%, respectively. Then, the data indicated that the disease with the highest mortality rate was nervous system diseases, which was 9.3%, especially pulmonary encephalopathy, the mortality rate was 21.7%. Furthermore, logistic regression analysis showed that age over 80 years, smoking long than 20 years, smoking more than 700 cigarettes per year, drinking, C-reactive protein (CRP) more than 50 mg/L, hyperglycemia and hypoproteinemia were the risk factors of COPD with complications (OR=3.488, 4.085, 4.086, 2.464, 2.208, 2.066, 11.804). Conclusion The incidence of COPD complications is relatively high, and the mortality also increase obviously. Therefore, more attention should be payed to the treatment and prevention for complications of COPD.