Grade evaluation of Carthamus tinctorius based on correlation of “biological activity-quality marker” / 中草药
Chinese Traditional and Herbal Drugs
; (24): 4683-4690, 2019.
Article
in Zh
| WPRIM
| ID: wpr-850818
Responsible library:
WPRO
ABSTRACT
Objective: To establish a Logistic model for quality assessment of Carthamus tinctorius based on content determination and bioactivity. Methods: A method to determinate hydroxy safflor yellow A by using ultra-high performance liquid chromatography (UPLC) was proposed. The activity of anticoagulant was reflected by thrombin time (TT) and the anti-oxidant activity was expressed by scavenging ability of hydroxyl radical and DPPH radical. Later, a Logistic model grade evaluation of C. tinctorius was constructed based on correlation analysis between content and biological activity Logistic.Results: The constructed Logistic model had outstanding stability and high prediction accuracy of grades and it divides 19 batches of C. tinctorius into four grades. Conclusion: The Logistic model based on content determination and biological activity is applicable to assess quality of C. tinctorius slices and provides some reference for quality control.
Full text:
1
Database:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Chinese Traditional and Herbal Drugs
Year:
2019
Document type:
Article