Pathogenesis and treatment of the syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis / 国际儿科学杂志

ABSTRACT

The syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA)is the most common cause of periodic fever in childhood.The diagnosis of PFAPA is typically made on clinical grounds.The patients usually show normal growth and development.The current pharmacological treatment includes corticosteroids for the management of febrile episodes, colchicine for the prophylaxis of febrile episodes, and other medication with unproven efficacy.Tonsillectomy is an option for selected patients.Usually PFAPA syndrome resolves during adolescence, but there is increasing evidence that this condition may persist into adulthood.This article reviews the pathogenesis and treatment of PFAPA in order to raise pediatricians′ awareness of this disease.