Comparison of gene chip detection results between spontaneous abortion and recurrent abortion / 中国医师进修杂志

ABSTRACT

Objective:By using array-based comparative genomic hybridzation (CGH), the karyotype of spontaneous abortion was detected to analyze the genetic background difference between initial abortion and recurrent abortion.Methods:From July 2016 to September 2019, patients diagnosed as spontaneous abortion in Dalian Women′s and Children′s Medical Center were collected continuously. The abortion tissue microarray was used to analyze.Results:A total of 618 cases were collected, 345 of whom met the inclusion criteria, 133 cases (38.55%) in spontaneous abortion group and 212 cases (61.45%) in recurrent abortion group. A total of 237 cases of abnormal chromosome were detected, among whom the incidence of trisomy 22 (10.14%), trisomy 16 (9.86%) and monosomy 19 (7.25%) was high. The abnormal rate of chromosome karyotype was lower in recurrent abortion group, but there was no significant statistical difference ( P>0.05). After analyzing different age and gestational age, there was no significant statistical difference between haplotype and trisomy ( P>0.05). Conclusions:Some abnormal karyotypes are more common in abortion tissues. In recurrent abortion, the abnormal rate of chromosome karyotype is lower, but there is no significant difference in genetic background between spontaneous abortion and recurrent abortion.