The effect and safety of monoclonal antibodies to calcitonin gene-related peptide and its receptor on migraine: a systematic review and meta-analysis / 中华神经科杂志
Chinese Journal of Neurology
; (12): 520-527, 2020.
Article
in Zh
| WPRIM
| ID: wpr-870838
Responsible library:
WPRO
ABSTRACT
Objective:
To evaluate the effect and safety of monoclonal antibodies to calcitonin gene-related peptide and its receptor (CGRP-mAbs) on migraine.Methods:
Database of PubMed, Embase, Cochrane, CNKI, Wangfang digital journals were searched for randomized controlled trials (RCTs) of CGRP-mAbs in treatment of migraine. Quality of enrolled literature was assessed by the software of Review Manager 5.3 and software of StataMP14 was employed to conduct meta analysis.Results:
A total of 13 RCTs were included, including 6 218 adult migraine patients (experimental group 2 679 patients, placebo group 3 539 patients). Meta analysis suggested that CGRP-mAbs for preventive treatment of migraine significantly reduced the monthly migraine days from baseline (standardized mean difference (SMD)=-0.35, 95% CI-0.4--0.3) and monthly acute migraine-specific medication consumption from baseline (SMD=-0.38, 95% CI-0.43--0.32), as compared with placebo group. CGRP-mAbs for preventive treatment of migraine significantly increased the ≥50% reduction from baseline in migraine days per month ( RR=1.65, 95% CI 1.54-1.76). The adverse events were similar between the CGRP-mAbs group and placebo group ( RR=1.06, 95% CI 1.01-1.10).Conclusion:
CGRP-mAbs are effective and safe for preventive treatment of migraine.
Full text:
1
Database:
WPRIM
Type of study:
Clinical_trials
/
Systematic_reviews
Language:
Zh
Journal:
Chinese Journal of Neurology
Year:
2020
Document type:
Article
Country of publication:
CHINA
/
CN
/
REPUBLIC OF CHINA