Analysis of hepatitis C virus infection status and risk factors among people in Chengdu / 公共卫生与预防医学

ABSTRACT

Objective To investigate the hepatitis C virus (HCV) infection status and risk factors among people in some areas of Sichuan, so as to provide scientific theoretical basis for disease prevention and control. Methods A multi-stage cluster random sampling method was used to select 79 132 permanent residents from 13 districts of Chengdu for anti-HCV testing and questionnaire survey. The distribution of anti-HCV positive was analyzed, and the risk factors of HCV infection were analyzed by case-control method. Results In this study, the investigation valid rate was 92.00% (72 805 / 79 132), and the overall anti-HCV positive rate was 0.82% (597/72805). The positive rate of anti-HCV in male was significantly higher than that in female (P2trend=31.257, P<0.001). Among different occupation groups, the positive rate of anti-HCV was the highest in farmer group (P<0.05), and was the lowest in student group (P<0.05). The districts with top 5 anti-HCV positive rates were Tianfu New District, Xindu District, Wenjiang District, Pidu District and Qingbaijiang District. The positive rate of anti-HCV in suburbs was significantly higher than that in main urban area (P<0.05). The ratio of HCV history, oral diagnosis and treatment history, invasive examination history, operation history, blood donation history, blood transfusion history, acupuncture history, tattoo history, syringes sharing history, toothbrush sharing, razor sharing and never using condom in the case group was significantly higher than that in the control group (P<0.05). Invasive examination, acupuncture, frequent sharing of toothbrush and razor were the high risk factors of HCV infection (P<0.05). Conclusion In Chengdu, the infection rate of HCV is relatively high among males, 51~ 60 years old, primary school and below, farmers and suburban population, moreover, invasive examination, acupuncture, frequent sharing of toothbrushes and razor are high risk factors for HCV infection. Therefore, health education on HCV infection-related knowledge and targeted intervention measures are of vital importance.