Analysis of the Different Therapeutic Effects in 21 Ph / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 38-42, 2021.
Article
in Zh
| WPRIM
| ID: wpr-880028
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To analyze the outcomes of the children suffered from philadelphia chromosome positive acute lymphoblastic leukemia (Ph@*METHODS@#21 cases of firstly diagnosed Ph@*RESULTS@#Among 21 patients, 17 were male and 4 were female with a median age of 8 years old (range, 4-12 years), the median follow-up time was 30 moths (range, 10-133 months). All the patients were treated with chemotherapy induced by the high-risk project of CCLG-ALL 2008. Among 14 patients treated with TKI plus chemotherapy, nine patients achieved complete remission. During 3 months after treatment, patients without complete molecular response or with the second complete remission and intensity desire of transplantation were treated with allo-HSCT, among 9 patients with allo-HSCT, six patients achieved long term survival.@*CONCLUSION@#At TKI era, TKI combined with strong chemotherapy can make Ph
Full text:
1
Database:
WPRIM
Main subject:
Philadelphia Chromosome
/
Retrospective Studies
/
Hematopoietic Stem Cell Transplantation
/
Protein Kinase Inhibitors
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Observational_studies
Limits:
Aged
/
Child
/
Female
/
Humans
/
Infant
/
Male
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2021
Document type:
Article