Influential factor and trend of specific IgG antibody titer in coronavirus disease 2019 convalescents / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1172-1175, 2020.
Article
in En
| WPRIM
| ID: wpr-880582
Responsible library:
WPRO
ABSTRACT
OBJECTIVES@#To explore the influential factors and titer trend of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific IgG antibody in convalescent patients with coronavirus disease 2019 (COVID-19), and to provide theoretical basis for the feasibility of clinical treatment of convalescent plasma.@*METHODS@#Colloidal gold immunochromatography assay was used to detect the SARS-CoV-2 specific IgG antibody and its titer in 113 convalescent patients with COVID-19 who were followed up from February 19, 2020 to April 6, 2020. The basic characteristics and treatment factors of patients in the high titer group (antibody titer≥1꞉160, @*RESULTS@#The difference in the clinical type of COVID-19, onset time, first admission C-reactive protein, absolute value of lymphocyte, absolute value of CD19@*CONCLUSIONS@#Male COVID-19 patients might be more likely to produce high titer SARS-CoV-2 specific IgG antibodies than female. The peak level of SARS-CoV-2 specific IgG antibody in convalescent patients is maintained for a short period. Using plasma from convalescent COVID-19 patients for treatment should be within 28 d after discharge.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Pneumonia, Viral
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Immunoglobulin G
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Immunization, Passive
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Pandemics
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Betacoronavirus
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SARS-CoV-2
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COVID-19
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Antibodies, Viral
Limits:
Female
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Humans
/
Male
Language:
En
Journal:
Journal of Central South University(Medical Sciences)
Year:
2020
Document type:
Article