HIF / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 333-344, 2021.
Article
in En
| WPRIM
| ID: wpr-880664
Responsible library:
WPRO
ABSTRACT
OBJECTIVES@#To analyze the expressions and distributions of hypoxia-inducible factor-1α (HIF-1α), CD147, and glucose transporter 1 (GLUT1) in epidermis from psoriasis vulgaris and normal people, and to explore the associations among these proteins and their roles in hypoxic HaCaT cell line.@*METHODS@#The expression levels of HIF-1α, CD147, and GLUT1 were determined by immunohistochemistry staining in skin biopsies from 48 psoriasis vularis patients and 33 healthy subjects. Cobalt chloride (CoCl@*RESULTS@#HIF-1α, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1α upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl@*CONCLUSIONS@#Glycolytic capacity increases in the injured keratinocytes of psoriasis vulgaris, suggesting that HIF-1α, CD147, and GLUT1 are associated with glycolysis, which can be considered as the promising targets for psoriasis therapy.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Psoriasis
/
Transcriptional Activation
/
Up-Regulation
/
Glucose Transporter Type 1
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Basigin
/
Glycolysis
Limits:
Humans
Language:
En
Journal:
Journal of Central South University(Medical Sciences)
Year:
2021
Document type:
Article