Research advances on haploidentical hematopoietic stem cell transplantation in the treatment of severe aplastic anemia in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 854-859, 2021.
Article
in En
| WPRIM
| ID: wpr-888493
Responsible library:
WPRO
ABSTRACT
Haploidentical hematopoietic stem cell transplantation is a recommended alternative therapy for children with severe aplastic anemia who lack a human leukocyte antigen (HLA)-identical sibling donor and do not respond well to immunosuppressive therapy; however, due to non-identical HLA, the patients may have donor-specific anti-HLA antibody, which may lead to a relatively high incidence rate of poor graft function. Compared with HLA-identical transplantation, conditioning regimen for haploidentical transplantation still needs to be explored. This article reviews the detection and treatment of donor-specific anti-HLA antibody, the selection of conditioning regimen, and the mechanism and treatment of poor graft function in haploidentical hematopoietic stem cell transplantation.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Transplantation, Homologous
/
Hematopoietic Stem Cell Transplantation
/
Transplantation Conditioning
/
Graft vs Host Disease
/
Anemia, Aplastic
Limits:
Child
/
Humans
Language:
En
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2021
Document type:
Article