Longitudinal Observation of Early-Onset Alzheimer’s Disease Dementia with Positive CSF Biomarkers/Negative Amyloid-β Positron-Emission Tomography
Journal of the Korean Neurological Association
; : 214-218, 2021.
Article
in Ko
| WPRIM
| ID: wpr-900896
Responsible library:
WPRO
ABSTRACT
We report a 61-year-old woman with clinical course for Alzheimer’s disease (AD) dementia and discordant amyloid-β positron-emission tomography (PET) and cerebrospinal fluid biomarkers. Brain magnetic resonance imaging revealed remarkable atrophy in the hippocampus. However, repeated delayed 18F-flutemetamol brain amyloid PET images with 1 year-interval revealed no amyloid deposition, whereas her CSF revealed low Aβ42, high total tau and p-tau181. This discordant amyloid-β PET and CSF biomarkers in this early-onset AD dementia might be associated with her low resilience or mixed pathology.
Full text:
1
Database:
WPRIM
Language:
Ko
Journal:
Journal of the Korean Neurological Association
Year:
2021
Document type:
Article