Value of heparin-binding protein in the diagnosis of severe infection in children: a prospective study / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 85-89, 2022.
Article
in En
| WPRIM
| ID: wpr-928571
Responsible library:
WPRO
ABSTRACT
OBJECTIVES@#To study the value of heparin-binding protein (HBP) in the diagnosis of severe infection in children.@*METHODS@#This study was a prospective observational study. The medical data of children who were admitted to the pediatric intensive care unit due to infection from January 2019 to January 2020 were collected. According to the diagnostic criteria for severe sepsis and sepsis, the children were divided into a severe sepsis group with 49 children, a sepsis group with 82 children, and a non-severe infection group with 33 children. The three groups were compared in terms of related biomarkers such as plasma HBP, serum C-reactive protein, serum procalcitonin, and platelet count. The receiver operating characteristic (ROC) curve was plotted to investigate the value of plasma HBP level in the diagnosis of severe infection (including severe sepsis and sepsis).@*RESULTS@#The severe sepsis and sepsis groups had a significantly higher plasma HBP level on admission than the non-severe infection group (P<0.05). Compared with the sepsis and non-severe groups, the severe sepsis group had significantly higher serum levels of C-reactive protein and procalcitonin and a significantly lower platelet count (P<0.05). Plasma HBP level had an area under the ROC curve of 0.590 in determining severe infection, with a sensitivity of 38.0% and a specificity of 82.4% (P<0.05).@*CONCLUSIONS@#There is an increase in plasma HBP level in children with severe infection, and plasma HBP level has a lower sensitivity but a higher specificity in the diagnosis of severe infection and can thus be used as one of the markers for the judgment of severe infection in children.
Key words
Full text:
1
Database:
WPRIM
Main subject:
C-Reactive Protein
/
Blood Proteins
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Biomarkers
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Prospective Studies
/
ROC Curve
/
Sepsis
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Antimicrobial Cationic Peptides
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Procalcitonin
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Child
/
Humans
Language:
En
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2022
Document type:
Article
Publication country:
CHINA
/
CN
/
REPUBLIC OF CHINA