Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 155-160, 2022.
Article
in En
| WPRIM
| ID: wpr-929246
Responsible library:
WPRO
ABSTRACT
Three new ursane-type triterpenoids, 3-oxours-12-en-20, 28-olide (1), 3β-hydroxyurs-12-en-20, 28-olide (2) and 3β-hydroxyurs-11, 13(18)-dien-20, 28-olide (3), were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis. Their structures were elucidated by a combination of extensive 1D- and 2D-NMR experiments, MS data and comparisons with literature reports. Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages, but no antibacterial activity was found at a concentration of 128 μg·mL-1.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Triterpenes
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Rosmarinus
Limits:
Animals
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2022
Document type:
Article