Clinical efficacy of combined therapy in children with stage 4 neuroblastoma / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 759-764, 2022.
Article
in Zh
| WPRIM
| ID: wpr-939659
Responsible library:
WPRO
ABSTRACT
OBJECTIVES@#To study the early clinical efficacy of combined therapy of stage 4 neuroblastoma.@*METHODS@#A retrospective analysis was performed on the medical data and follow-up data of 14 children with stage 4 neuroblastoma who were diagnosed in Hong Kong University-Shenzhen Hospital from January 2016 to June 2021.@*RESULTS@#The median age of onset was 3 years and 7.5 months in these 14 children. Among these children, 9 had positive results of bone marrow biopsy, 4 had N-Myc gene amplification, 13 had an increase in neuron-specific enolase, and 7 had an increase in vanilmandelic acid in urine. Based on the results of pathological examination, differentiated type was observed in 6 children, undifferentiated type in one child, mixed type, in one child and poorly differentiated type in 6 children. Of all the children, 10 received chemotherapy with the N7 regimen (including 2 children receiving arsenic trioxide in addition) and 4 received chemotherapy with the Rapid COJEC regimen. Thirteen children underwent surgery, 14 received hematopoietic stem cell transplantation, and 10 received radiotherapy. A total of 8 children received Ch14.18/CHO immunotherapy, among whom 1 child discontinued due to anaphylactic shock during immunotherapy, and the other 7 children completed Ch14.18/CHO treatment without serious adverse events, among whom 1 child was treated with Lu177 Dotatate 3 times after recurrence and is still undergoing chemotherapy at present. The median follow-up time was 45 months for all the 14 children. Four children experienced recurrence within 2 years, and the 2-year overall survival rate was 100%; 4 children experienced recurrence within 3 years, and 7 achieved disease-free survival within 3 years.@*CONCLUSIONS@#Multidisciplinary combined therapy is recommended for children with stage 4 neuroblastoma and can help them achieve better survival and prognosis.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Antineoplastic Combined Chemotherapy Protocols
/
Radionuclide Imaging
/
Retrospective Studies
/
Treatment Outcome
/
Combined Modality Therapy
/
Positron-Emission Tomography
/
Neuroblastoma
Type of study:
Observational_studies
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2022
Document type:
Article