Effects of Local Mild Hypothermia on Dopamine and 5-Hydroxytryptamine in Basal Ganglion of Neonatal Rabbits with Bilirubin Encephalopathy / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
; (12): 35-37, 2010.
Article
in Zh
| WPRIM
| ID: wpr-959194
Responsible library:
WPRO
ABSTRACT
@# ObjectiveTo observe the effects of local mild hypothermia at different time on dopamine (DA) and 5-hydroxytryptamine (5-HT) concentration in rabbits brain basal ganglion with bilirubin encephalopathy. MethodsThe model of bilirubin encephalopathy was established, and treated with mild hypothermia for different time. The DA and 5-HT in the basal ganglion were detected with fluorescence spectrophotometry. ResultsThe DA and the 5-HT decreased in the basal ganglion significantly after modeling (P<0.01), and increased when treated for 6 h, 12 h or 24 h (P<0.01). ConclusionLocal mild hypothermia can significantly reduce the disorder of DA and 5-HT during bilirubin encephalopathy. The longer the hypothermia, the better the effect is.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Rehabilitation Theory and Practice
Year:
2010
Document type:
Article