Extracellular Signal-regulated Kinase 1/2 Signaling Regulates Cell Invasion:a Review / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 155-160, 2023.
Article
in Zh
| WPRIM
| ID: wpr-970461
Responsible library:
WPRO
ABSTRACT
Extracellular signal-regulated kinase 1/2 (ERK1/2) is a serine/threoninekinase involved in the signal transduction cascade of Ras-Raf-mitogen-activated protein kinase (MEK)-ERK.It participates in the cell growth,proliferation and even invasion by regulating gene transcription and expression.The occurrence of a variety of diseases such as lung cancer,liver cancer,ovarian cancer,cervical cancer,endometriosis,and preeclampsia,as well the metastasis and disease progression,is closely associated with the regulation of cell invasion by ERK1/2 signaling pathway.Therefore,exploring the regulation of ERK1/2 signaling on cell invasion and its role in pathogenesis of diseases may help to develop more effective treatment schemes.This article introduces recent progress in the regulation of ERK1/2 signaling on cell invasion and the role of such regulation in diseases,with a view to give new insights into the clinical treatment of ERK 1/2-related diseases.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Signal Transduction
/
Cell Cycle
/
Mitogen-Activated Protein Kinases
/
Mitogen-Activated Protein Kinase 3
/
Cell Proliferation
Limits:
Female
/
Humans
/
Pregnancy
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2023
Document type:
Article