Expression of caspase-3 in the rat brain following pentylenetetrazole-induced epilepsy / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
; (12): 343-344, 2005.
Article
in Zh
| WPRIM
| ID: wpr-978105
Responsible library:
WPRO
ABSTRACT
@#ObjectiveTo investigate the expression of caspase-3 in the brain of acutely pentylenetetrazole(PTZ)-kindled rats.MethodsThe caspase-3 positive cells were revealed using immunohistochemical SP method. CMIAS image analysis system was used to analyse the expression of caspase-3 hemi-quantitatively. ResultsFollowing PTZ induced epilepsy, the expression of caspase-3 increased both in the hippocampus and in the cortex, and that was more remarkable in the hippocampus than in the cortex.ConclusionCaspase-3 may be activated during neuronal apoptosis after epilepsy. Hippocampus is more sensitive to the neuronal damage due to epilepsy than the cortex is.
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Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Rehabilitation Theory and Practice
Year:
2005
Document type:
Article