Research progress of familial hereditary prostate cancer / 中华泌尿外科杂志
Chinese Journal of Urology
; (12): 68-71, 2023.
Article
in Zh
| WPRIM
| ID: wpr-993978
Responsible library:
WPRO
ABSTRACT
Hereditary prostate cancer has the highest hereditary rate in men cancers. Genes associated with hereditary prostate cancer susceptibility include mismatch repair genes (MLH1, MSH2, MSH6 and PMS2) and homologous recombination genes (BRCA1/2, ATM, PALB2, CHEK2), and single nucleotide polymorphisms and copy number variants also play a role in genetic mutations. Early onset, rapid disease progression and locally advanced stage are the main features of hereditary prostate cancer. Patients with potentially hereditary prostate cancer would benefit from undergoing genetic testing or counseling. This article reviews the current status of the prevalence, incidence characteristics, and etiology of familial hereditary prostate cancer and other research advances.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Urology
Year:
2023
Document type:
Article