INTRODUCTION:
The
prevalence of
metabolic syndrome (MetS) and MetS-related
stroke is set to increase dramatically in coming decades. MetS is a complex
disease that includes endothelial dysfunction,
insulin resistance, diabetes,
hypertension, ectopic
obesity, and dyslipidaemia and an increased
risk of cardiovascular events. One function of
high-density lipoprotein (HDL)
cholesterol (HDL-C) is the
cholesterol-efflux pathway, which is the pathway where
cholesterol is removed from
macrophages within the arterial walls
back into the bloodstream and out to the
liver. As one of the key functions of HDL, their hypothesis was that if they could
measure HDL-C-efflux capacity, they would have a better handle on the
role of HDL in
atherosclerosis. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between HDL-C functionality and MetS. The aim of this study is to examine this
association of HDL-C functionality with MetS in different ages and
sex.
METHODS AND
ANALYSIS:
The update
systematic review and
meta-analysis will be conducted using published studies that
will be identified from
electronic databases (i.e.,
PubMed, EMBASE, Web of
Science, and Google Scholar). Studies that examined the
association between HDL-C functionality and MetS; focused on cohort, case-control, and
cross-sectional studies; were conducted among in
adults aged 40 to 70 years; provided sufficient data for calculating
odds ratio or
relative risk with a 95%
confidence interval; were published as original articles written in English or other
languages; and have been published until January 2018
will be included. Study selection,
data collection, quality assessment, and statistical syntheses
will be conducted based on discussions among
investigators.
