BACKGROUND:
The
prevalence of
metabolic syndrome (MetS) and MetS-related
stroke is set to increase dramatically in coming decades. MetS is a complex
disease that includes endothelial dysfunction,
insulin resistance, diabetes,
hypertension, ectopic
obesity, and dyslipidaemia, and an increased
risk of cardiovascular events. However, there are no systematic analyses, or well conducted meta-analyses to evaluate the relationship between
epicardial adipose tissue (EAT) and (MetS). The aim of this study is to examine this
association of EAT with MetS in different ages and
sex.
METHODS:
The update
systematic review, and
meta-analysis will be conducted using published studies that
will be identified from
electronic databases (ie,
PubMed, EMBASE, Web of
Science, and Google Scholar. Studies that firstly, examined the
association between EAT and MetS, secondly, focus on cohort, case-control, and
cross-sectional studies, thirdly, were conducted among in
adults aged between 40 and 70 years, fourth, provided sufficient data for calculating ORs or
relative risk with a 95% CI, fifth, were published as original articles written in English or other
languages, and sixth, have been published until January year 2018
will be included. Study selection,
data collection, quality assessment, and statistical syntheses
will be conducted based on discussions among
investigators.
RESULTS:
Ethics approval was not required for this study because it was based on published studies. The results and findings of this study
will be submitted and published in a scientific peer-reviewed journal. This study
will provide a high quality synthesis on the
association of EAT and MetS.
CONCLUSION:
This
systematic review will provide evidence to assess whether there is a strong
association of EAT and MetS, and its components.
