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Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapy
Abreu, Mariana Gouvêa Latini; Kawamoto, Dione; Mayer, Marcia Pinto Alves; Pascoal, Vinicius D'Avila Bitencourt; Caiaffa, Karina Sampaio; Zuza, Elizangela P; Duque, Cristiane; Camargo, Gabriela Alessandra da Cruz Galhardo.
Afiliación
  • Abreu, Mariana Gouvêa Latini; Universidade Federal Fluminense. Departamento de Odontologia. Nova Friburgo. BR
  • Kawamoto, Dione; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. São Paulo. BR
  • Mayer, Marcia Pinto Alves; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. São Paulo. BR
  • Pascoal, Vinicius D'Avila Bitencourt; Universidade Federal Fluminense. Departamento de Ciências Básicas. Nova Friburgo. BR
  • Caiaffa, Karina Sampaio; Universidade Estadual Paulista. Faculdade de Odontologia de Araçatuba. Departamento de Endodontia. Araçatuba. BR
  • Zuza, Elizangela P; Universidade Federal Fluminense. Departamento de Odontologia. Nova Friburgo. BR
  • Duque, Cristiane; Universidade Estadual Paulista. Faculdade de Odontologia de Araçatuba. Departamento de Odontopediatria e Saúde Pública. Araçatuba. BR
  • Camargo, Gabriela Alessandra da Cruz Galhardo; Universidade Federal Fluminense. Departamento de Odontologia. Nova Friburgo. BR
J. appl. oral sci ; 27: e20180205, 2019. tab, graf
Artículo en Inglés | LILACS, BBO - Odontología | ID: biblio-1002408
Biblioteca responsable: BR1.1
ABSTRACT
Abstract Porphyromonas gingivalis is one of the most important Gram-negative anaerobe bacteria involved in the pathogenesis of periodontitis. P. gingivalis has an arsenal of specialized virulence factors that contribute to its pathogenicity. Among them, fimbriae play a role in the initial attachment and organization of biofilms. Different genotypes of fimA have been related to length of fimbriae and pathogenicity of the bacterium. Objectives The aim of this study was to identify 5 types of fimA genotype strains in smokers and nonsmokers with periodontitis, before and after periodontal therapy. Material and Methods Thirty-one patients with periodontitis harboring P. gingivalis were selected 16 nonsmokers (NS) and 15 smokers (SM). Clinical and microbiological parameters were evaluated at baseline and 3 months after periodontal treatment, namely plaque index, bleeding on probe, probing depth, gingival recession and clinical attachment level. The frequency of P. gingivalis and fimA genotype strains were determined by polymerase chain reaction. Results Type I fimA was detected in the majority of SM and NS at baseline, and the frequency did not diminish after 3 months of treatment. The frequency of type II genotype was higher in SM than NS at baseline. After 3 months, statistical reduction was observed only for types II and V fimA genotypes in SM. The highest association was found between types I and II at baseline for NS (37.5%) and SM (53.3%). Conclusion The most prevalent P. gingivalis fimA genotypes detected in periodontal and smoker patients were genotypes I and II. However, the presence of fimA genotype II was higher in SM. Periodontal treatment was effective in controlling periodontal disease and reducing type II and V P. gingivalis fimA.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: BBO - Odontología / LILACS Asunto principal: Periodontitis / Fumar / Porphyromonas gingivalis / Proteínas Fimbrias Tipo de estudio: Estudio pronóstico Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: J. appl. oral sci Asunto de la revista: Odontología Año: 2019 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Estadual Paulista/BR / Universidade Federal Fluminense/BR / Universidade de São Paulo/BR

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: BBO - Odontología / LILACS Asunto principal: Periodontitis / Fumar / Porphyromonas gingivalis / Proteínas Fimbrias Tipo de estudio: Estudio pronóstico Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: J. appl. oral sci Asunto de la revista: Odontología Año: 2019 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Estadual Paulista/BR / Universidade Federal Fluminense/BR / Universidade de São Paulo/BR
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