Nasal polyposis: more than a chronic inflammatory disorder-a disease of mechanical dysfunction - the São paulo position
Int. arch. otorhinolaryngol. (Impr.)
; 23(2): 241-249, 2019. ilus, tab
Artículo
en Inglés
| LILACS
| ID: biblio-1015650
Biblioteca responsable:
BR66.1
ABSTRACT
Introduction:
The importance of our study lies in the fact that we have demonstrated the occurrence ofmechanical dysfunction within polypoid tissues, which promotes the development of polyps in the nasal cavity.Objective:
To change the paradigm of nasal polyposis (NP). In this new conception, the chronic nasal inflammatory process that occurs in response to allergies, to pollution, to changes in the epithelial barrier, or to other factors is merely the trigger of the development of the disease in individuals with a genetic predisposition to an abnormal tissue remodeling process, which leads to a derangement of the mechanical properties of the nasal mucosa and, consequently, allows it to grow unchecked. Data Synthesis We propose a fundamentally new approach to intervening in the pathological process of NP, addressing biomechanical properties, fluid dynamics, and the concept of surface tension.Conclusion:
The incorporation of biomechanical knowledge into our understanding of NP provides a new perspective to help elucidate the physiology and the pathology of nasal polyps, and new avenues for the treatment and cure of NP (AU)
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
LILACS
Asunto principal:
Pólipos Nasales
/
Inflamación
Límite:
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Int. arch. otorhinolaryngol. (Impr.)
Asunto de la revista:
Otorrinolaringologia
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Bélgica
/
Brasil
Institución/País de afiliación:
Department of Biochemistry, Unifesp/BR
/
Department of Medicine, Nephrology Division, Unifesp/BR
/
Department of Ophthalmology and Visual Sciences, Unifesp/BR
/
Department of Otolaryngology - Head and Neck Surgery, Unifesp/BR
/
Department of Otolaryngology, UERJ/BR
/
Department of Otolaryngology, UFPE/BR
/
Department of Otolaryngology, USP/BR
/
Ear, Nose and Throat Department,, University of Ghent/BE
/
Laboratory of Microrheology and Molecular Physiology, Institute of Physics, USP/BR
/
Proteinscience, Proteomics and Epigenetic Signaling, Department of Biomedical Sciences, University of Antwerp/BE