Strong sex bias in elite control of paediatric HIV infection
AIDS
; 33(1): 67-75, Jan. 2019. ilus, tab
Article
en En
| SES-SP, SESSP-IIERPROD, SES-SP
| ID: biblio-1021225
Biblioteca responsable:
BR31.1
Ubicación: BR31.1; 2019_P-002
ABSTRACT
BACKGROUND:
Reports of posttreatment control following antiretroviral therapy (ART) have prompted the question of how common immune control of HIV infection is in the absence of ART. In contrast to adult infection, where elite controllers have been very well characterized and constitute approximately 0.5% of infections, very few data exist to address this question in paediatric infection.METHODS:
We describe 11 ART-naive elite controllers from 10 cohorts of HIV-infected children being followed in South Africa, Brazil, Thailand, and Europe.RESULT:
All but one of the elite controllers (91%) are females. The median age at which control of viraemia was achieved was 6.5 years. Five of these 11 (46%) children lost control of viraemia at a median age of 12.9 years. Children who maintained control of viraemia had significantly higher absolute CD4þ cell counts in the period of elite control than those who lost viraemic control. On the basis of data available from these cohorts, the prevalence of elite controllers in paediatric infection is estimated to be 510-fold lower than in adults.CONCLUSION:
Although conclusions are limited by the study design, these data suggest that, whilst paediatric elite control can be achieved, compared with adult elite controllers, this occurs rarely, and takes some years after infection to achieve. Also, loss of immune control arises in a high proportion of children and often relatively rapidly. These findings are consistent with the more potent antiviral immune responses observed in adults and in femalesPalabras clave
Texto completo:
1
Colección:
06-national
/
BR
Base de datos:
SES-SP
/
SESSP-IIERPROD
Asunto principal:
Infecciones por VIH
/
Terapia Antirretroviral Altamente Activa
Tipo de estudio:
Risk_factors_studies
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
AIDS
Año:
2019
Tipo del documento:
Article