Your browser doesn't support javascript.
loading
Inflammatory cytokines in leprosy reactions and periodontal diseases
São Paulo; s.n; 2018. 9 p. tab, graf.
Non-conventional en En | HANSEN, SES-SP, HANSENIASE, SESSP-ILSLPROD, SES-SP, SESSP-ILSLACERVO, SES-SP | ID: biblio-1024912
Biblioteca responsable: BR191.1
Ubicación: BR191.1; 9497/S
ABSTRACT
The inflammatory cytokines involved in the immune response to chronic periodontal disease (CPD) in the context of leprosy reactions (LR) were analyzed in 57 new cases of multibacillary leprosy (MBL). They were stratified by the presence of CPD and LR. Messenger RNA (mRNA) expression of inflammatory mediators was determined by qRT-PCR using skin biopsy and by ELISA using serum samples, maintaining 5% of significance level in ANOVA and correlation analyses. Twenty-three (40.4%) patients presented the first LR, whereas 22 (45.0%) patients presented CPD. IL-4 and IL-6 serum levels were significantly lower in patients with CPD and LR than in patients without CPD but with LR; IFN-γ serum levels were higher in patients with CPD and LR than in patients with no CPD and no LR; IL-4 serum levels were negatively correlated with TNF-α gene expression, while IL-6 serum levels were positively correlated with IFN-γ gene expression, in the skin of subjects with CPD and LR. The presence of DPC in individuals with LR immunoregulated IL-6, IFN-γ, and IL-4 concentrations. The presence of DPC decreased serum levels of IL-6 and IL-4 in reactional individuals. CPD concomitant to LR resulted in increased IFN-γ serum levels.
Asunto(s)
Palabras clave
Texto completo: 1 Colección: 06-national / BR Base de datos: HANSEN / HANSENIASE / SES-SP / SESSP-ILSLACERVO / SESSP-ILSLPROD Asunto principal: Enfermedades Periodontales / Lepra Multibacilar Idioma: En Año: 2018 Tipo del documento: Non-conventional Pais de publicación: Brasil
Texto completo: 1 Colección: 06-national / BR Base de datos: HANSEN / HANSENIASE / SES-SP / SESSP-ILSLACERVO / SESSP-ILSLPROD Asunto principal: Enfermedades Periodontales / Lepra Multibacilar Idioma: En Año: 2018 Tipo del documento: Non-conventional Pais de publicación: Brasil