Prevention of severe clinical signs and pathological lesions of leptospirosis in experimentally challenged dogs
In. The University of the West Indies, Faculty of Medical Sciences. Faculty of Medical Sciences, Research Day. St. Augustine, Caribbean Medical Journal, March 21, 2019. .
No convencional
en Inglés
| MedCarib
| ID: biblio-1026258
Biblioteca responsable:
TT5
ABSTRACT
Objective:
To prevent severe clinical and pathological findings of leptospirosis in dogs vaccinated against L. interrogans serovar Copenhageni. Design andMethodology:
Two vaccination-challenge experiments involving 22 dogs were performed using a vaccine prepared from formalin-killed cultures of L. interrogans serovar Copenhageni. The dogs were challenged by administering a suspension of 1 x 109 of a virulent strain of serovar Copenhageni (8 mL) at 2 weeks (Study 1 Onset of immunity) and 14 months (Study 2 Duration of immunity) after primary and secondary vaccinations. Each dog was observed for clinical signs of leptospirosis for five weeks post-challenge (PC). Any dog which showed irreversible clinical signs of leptospirosis was humanely euthanized, and a necropsy performed.Results:
One (20.0 %) vaccinated puppy in Study 1 showed mild clinical signs (PC) which lasted for one day. Five (100.0 %) non-vaccinated (controls) puppies exhibited irreversible signs of acute severe leptospirosis PC, as well as significant postmortem lesions consistent with leptospiral infection. In Study 2, no clinical signs were exhibited by the vaccinated group of dogs PC, while two (40.0 %) non-vaccinated dogs exhibited mild clinical signs for 2 to 3 days, after which they recovered.Conclusions:
The vaccine was successful in protecting vaccinated dogs against acute leptospirosis 2 weeks and 14 months after a vaccination schedule of two doses of the bacterin (primary and booster doses), since all vaccinated dogs were clinically normal after challenge with a virulent inoculum of serovar Copenhageni.
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Colección:
Bases de datos internacionales
Contexto en salud:
Agenda de Salud Sostenible para las Américas
/
ODS3 - Salud y Bienestar
Problema de salud:
Objetivo 10: Enfermedades transmisibles
/
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
Base de datos:
MedCarib
Asunto principal:
Leptospirosis
Tipo de estudio:
Estudio diagnóstico
Límite:
Animales
País/Región como asunto:
Caribe Inglés
/
Trinidad y Tobago
Idioma:
Inglés
Año:
2019
Tipo del documento:
No convencional
Institución/País de afiliación:
The University of the West Indies/TT
/
The University of the West Indies/US