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New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
List, Edward O; Berryman, Darlene E; Jensen, Elizabeth A; Kulkarni, Prateek; McKenna, Savannah; Kopchick, John J.
Afiliación
  • List, Edward O; Ohio University. The Edison Biotechnology Institute. Athens. US
  • Berryman, Darlene E; Ohio University. The Edison Biotechnology Institute. Athens. US
  • Jensen, Elizabeth A; Ohio University. The Edison Biotechnology Institute. Athens. US
  • Kulkarni, Prateek; Ohio University. The Edison Biotechnology Institute. Athens. US
  • McKenna, Savannah; Ohio University. The Edison Biotechnology Institute. Athens. US
  • Kopchick, John J; Ohio University. The Edison Biotechnology Institute. Athens. US
Arch. endocrinol. metab. (Online) ; 63(6): 557-567, Nov.-Dec. 2019. tab, graf
Article en En | LILACS | ID: biblio-1055021
Biblioteca responsable: BR1.1
ABSTRACT
ABSTRACT In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue "global". In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines. Arch Endocrinol Metab. 2019;63(6)557-67
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Receptores de Somatotropina / Hormona del Crecimiento Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Receptores de Somatotropina / Hormona del Crecimiento Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Brasil