Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 42(1): 14-21, Jan.-Feb. 2020. tab
Artículo
en Inglés
| LILACS
| ID: biblio-1055366
Biblioteca responsable:
BR1.1
ABSTRACT
Objective:
This study aimed to determine if personality disorder (PD) predicted functional outcomes in patients with major depressive disorder (MDD).Methods:
Data (n=71) from a double-blind, randomized, placebo-controlled 12-week trial assessing the efficacy of 200 mg/day adjunctive minocycline for MDD were examined. PD was measured using the Standardized Assessment of Personality Abbreviated Scale. Outcome measures included Clinical Global Impression - Improvement (CGI-I), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social and Occupational Functioning Scale (SOFAS), and Range of Impaired Functioning (RIFT). Analysis of covariance was used to examine the impact of PD (dichotomized factor [≥ 3] or continuous measure) on the outcome measures-treatment group correlation.Results:
PD was identified in 69% of the sample. After adjusting for age, sex, and baseline scores for each of the outcome measures, there was no significant difference between participants with and without PD on week 12 scores for any of the outcome measures (all p > 0.14).Conclusion:
In this secondary analysis of a primary efficacy study, PD was a common comorbidity among those with MDD, but was not a significant predictor of functional outcomes. This study adds to the limited literature on PD in randomized controlled trials for MDD. Clinical trial registration ACTRN12612000283875.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Contexto en salud:
Agenda de Salud Sostenible para las Américas
Problema de salud:
Objetivo 9: Enfermedades no transmisibles y salud mental
Base de datos:
LILACS
Asunto principal:
Trastornos de la Personalidad
/
Trastorno Depresivo Mayor
/
Minociclina
/
Antidepresivos
Tipo de estudio:
Ensayo clínico controlado
/
Estudio pronóstico
/
Investigación cualitativa
Aspecto:
Preferencia del paciente
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Asunto de la revista:
Psiquiatria
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Australia
/
Tailandia
Institución/País de afiliación:
Barwon Health, Deakin University/AU
/
Chulalongkorn University/TH
/
University of Melbourne/AU
/
University of Sydney/AU