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Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas
Echeverría, Luis Eduardo; González, Clara Isabel; Hernandez, Julio Cesar Mantilla; Díaz, Martha Lucia; Eduardo Nieto, Javier; López-Romero, Luis Alberto; Rivera, Julián David; Suárez, Edwin Uriel; Ochoa, Sergio Alejandro Gómez; Rojas, Lyda Z; Morillo, Carlos A.
Afiliación
  • Echeverría, Luis Eduardo; Fundación Cardiovascular de Colombia. Grupo de Estudios Epidemiológicos y Salud Pública-FCV. Floridablanca. CO
  • González, Clara Isabel; Universidad Industrial de Santander. Faculty of Medicine. Grupo de Inmunología y Epidemiología Molecular GIEM. Santander. CO
  • Hernandez, Julio Cesar Mantilla; Universidad Industrial de Santander. Faculty of Medicine. Grupo de Inmunología y Epidemiología Molecular GIEM. Santander. CO
  • Díaz, Martha Lucia; Universidad Industrial de Santander. Faculty of Medicine. Grupo de Inmunología y Epidemiología Molecular GIEM. Santander. CO
  • Eduardo Nieto, Javier; Universidad Cooperativa de Colombia. Veterinary Department. Bucaramanga. CO
  • López-Romero, Luis Alberto; Fundación Cardiovascular de Colombia. Research Institute. Research Group and Development of Nursing Knowledge - GIDCEN-FCV. Floridablanca. CO
  • Rivera, Julián David; Fundación Cardiovascular de Colombia. Heart Failure and Heart Transplant Clinic. Floridablanca. CO
  • Suárez, Edwin Uriel; Fundación Cardiovascular de Colombia. Heart Failure and Heart Transplant Clinic. Floridablanca. CO
  • Ochoa, Sergio Alejandro Gómez; Fundación Cardiovascular de Colombia. Grupo de Estudios Epidemiológicos y Salud Pública-FCV. Floridablanca. CO
  • Rojas, Lyda Z; Fundación Cardiovascular de Colombia. Research Institute. Research Group and Development of Nursing Knowledge - GIDCEN-FCV. Floridablanca. CO
  • Morillo, Carlos A; University of Calgary. Libin Cardiovascular Institute of Alberta. Department of Cardiac Sciences. Alberta. CA
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;53: e20190477, 2020. tab, graf
Article en En | LILACS | ID: biblio-1057272
Biblioteca responsable: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

Benznidazole (BZL) and Nifurtimox (NFX) are the pharmacological treatment for acute phase Chagas Disease (CD); however, therapy resistance and residual mortality development remain important unresolved issues. Posaconazole (POS) has shown a trypanocidal effect in vivo and in vitro. Thus, this study aimed at comparing the T. Cruzi parasitic load-reducing effect of the combination of BZL+POS against that of monotherapy with either, during acute phase CD, in an experimental murine model. METHODS Nineteen Wistar rats were randomly allocated to four groups and inoculated with the trypomastigotes of T. cruzi strain´s JChVcl1. The rats were administered anti-parasites from day 20-29 post-infection. The Pizzi and Brener method was used for parasitemia measurement. Longitudinal data analysis for the continuous outcome of repeated measures was performed using parasitemia as the outcome measured at days 20, 22, 24, 27, and 29 post-infection. RESULTS All four groups had similar parasitic loads (p=0.143) prior to therapy initiation. Among the three treatment groups, the BZL+POS (n=5) group showed the highest mean parasitic load reduction (p=0.000) compared with the control group. Likewise, the BZL+POS group rats showed an earlier therapeutic effect and were the only ones without parasites in their myocardial samples.

CONCLUSIONS:

Treatment of acute phase CD with BZL+POS was more efficacious at parasitemia and myocardial injury reduction, compared with monotherapy with either.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Triazoles / Tripanocidas / Enfermedad de Chagas / Parasitemia / Nitroimidazoles Límite: Animals Idioma: En Revista: Rev. Soc. Bras. Med. Trop Asunto de la revista: MEDICINA TROPICAL Año: 2020 Tipo del documento: Article País de afiliación: Canadá / Colombia Pais de publicación: Brasil

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Triazoles / Tripanocidas / Enfermedad de Chagas / Parasitemia / Nitroimidazoles Límite: Animals Idioma: En Revista: Rev. Soc. Bras. Med. Trop Asunto de la revista: MEDICINA TROPICAL Año: 2020 Tipo del documento: Article País de afiliación: Canadá / Colombia Pais de publicación: Brasil