Antigenic cross-reactivity and immunogenicity of Bothrops venomsfrom snakes of the Amazon region
Toxicon
; 55(4): 881-887, Dec 29, 2009.
Article
en En
| SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO
| ID: biblio-1068248
Biblioteca responsable:
BR78.1
Ubicación: BR78.1
ABSTRACT
Snakebites are still a critical public health problem in developing countries or isolated areas. In Brazil, the North Region has a high distribution coefficient worsened by the significant number of eventually unreported cases, due to difficulties in access to healthservices, to the natural geographic barriers and the vast territory. In the Rio Negro area, the species Bothrops atrox, Bothrops brazili, Lachesis muta muta and Bothriopsis taeniata arethought to be the major species responsible for snakebites. The aim of this study was to qualitatively and quantitatively determine the antigenic cross-reactivity and expression oftoxins and the immunogenicity of Bothrops venom species of the Amazon and to evaluate the general efficacy of the therapeutic sera. The in vivo assays demonstrated that the defibrinating activity of B. taeniata venom was absent but that the lethal and hemorrhagic properties were more intense than in the B. atrox venom. The results evidence venom variability among the two B. atrox populations from two distinct Amazonian regions, which may reveal a subjacent speciation process. The results point to new aspects that mayguide the improvement of anti-Bothropic therapeutic serum.
Palabras clave
Buscar en Google
Colección:
06-national
/
BR
Base de datos:
SES-SP
/
SESSP-IBACERVO
/
SESSP-IBPROD
Asunto principal:
Venenos
/
Bothrops
/
Toxicidad
Idioma:
En
Revista:
Toxicon
Año:
2009
Tipo del documento:
Article